Inhibition of HIV-1 fusion with small interfering RNAs targeting the chemokine coreceptor CXCR4

@article{Zhou2004InhibitionOH,
  title={Inhibition of HIV-1 fusion with small interfering RNAs targeting the chemokine coreceptor CXCR4},
  author={Naiming Zhou and Jianfei Fang and Muhammad Dauda Mukhtar and Edward Acheampong and R W Pomerantz},
  journal={Gene Therapy},
  year={2004},
  volume={11},
  pages={1703-1712}
}
RNA interference (RNAi) is an evolutionarily conserved process by which plants and animals protect their genomes utilizing small, double-stranded RNAs to degrade target RNAs in a sequence-specific manner. Post-transcriptional gene silencing by these moieties can lead to degradation of both cellular and viral RNAs. It has recently been shown that double-stranded, small interfering RNAs (siRNAs) of 21–25 nucleotides can be transfected into relevant cells to target specific RNAs. This approach was… CONTINUE READING

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RNA interference meets HIV-1: Will silence be golden?

Nature Medicine • 2002
View 2 Excerpts
Highly Influenced

fulminant hepatitis

O Voinnet, C Lederer, DC. Baulcombe
Nat Med • 2003

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