Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion

@inproceedings{Vega2011InhibitionOH,
  title={Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion},
  author={Michelle de la Vega and Mariana Marin and Naoyuki Kondo and Kosuke Miyauchi and Yuri Kim and Richard M Epand and Gregory B. Melikyan},
  booktitle={Retrovirology},
  year={2011}
}
We recently provided evidence that HIV-1 enters HeLa-derived TZM-bl and lymphoid CEMss cells by fusing with endosomes, whereas its fusion with the plasma membrane does not proceed beyond the lipid mixing step. The mechanism of restriction of HIV-1 fusion at the cell surface and/or the factors that aid the virus entry from endosomes remain unclear. We examined HIV-1 fusion with a panel of target cells lines and with primary CD4+ T cells. Kinetic measurements of fusion combined with time-resolved… CONTINUE READING
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