Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron

Abstract

RNA interference (RNAi) is a powerful approach to inhibit human immunodeficiency virus type 1 (HIV-1) replication. However, HIV-1 can escape from RNAi-mediated antiviral therapy by selection of mutations in the targeted sequence. To prevent viral escape, multiple small interfering RNAs (siRNAs) against conserved viral sequences should be combined. Ideally… (More)
DOI: 10.1093/nar/gkn109

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