Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine.

@article{Ridley2003InhibitionOH,
  title={Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine.},
  author={J M Ridley and James T Milnes and Yin Zhang and Harry J. Witchel and Jules C. Hancox},
  journal={The Journal of physiology},
  year={2003},
  volume={549 Pt 3},
  pages={667-72}
}
4-Aminopyridine (4-AP) has been used extensively to study transient outward K+ current (ITO,1) in cardiac cells and tissues. We report here inhibition by 4-AP of HERG (the human ether-à-go-go-related gene) K+ channels expressed in a mammalian cell line, at concentrations relevant to those used to study ITO,1. Under voltage clamp, whole cell HERG current (IHERG) tails following commands to +30 mV were blocked with an IC50 of 4.4 +/- 0.5 mM. Development of block was contingent upon HERG channel… CONTINUE READING

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