Inhibition of HER-2/neu kinase impairs androgen receptor recruitment to the androgen responsive enhancer.

@article{Liu2005InhibitionOH,
  title={Inhibition of HER-2/neu kinase impairs androgen receptor recruitment to the androgen responsive enhancer.},
  author={Yuanbo Liu and Samarpan Majumder and W. Calvin McCall and Carolyn I. Sartor and James L. Mohler and Christopher William Gregory and H Shelton Earp and Young E. Whang},
  journal={Cancer research},
  year={2005},
  volume={65 8},
  pages={
          3404-9
        }
}
Advanced prostate cancer invariably recurs despite androgen deprivation therapy. The androgen receptor (AR) likely plays a key role in this progression and in the continued survival and proliferation of prostate cancer cells in the low androgen environment. Cross-talk with growth factor receptors, such as epidermal growth factor receptor (EGFR) family, has been postulated as a potential mechanism to activate AR in recurrent prostate cancer. We have investigated the role of HER-2/neu (ErbB-2… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 49 CITATIONS

PTEN, Longevity and Age-Related Diseases

VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

Similar Papers

Loading similar papers…