Inhibition of HDAC8 and HDAC9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to TLR ligands.

Abstract

Epidermal keratinocytes participate in immune defense through their capacity to recognize danger, trigger inflammation, and resist infection. However, normal skin immune function must tolerate contact with an abundant community of commensal microbes without inflammation. We hypothesized that microbial environmental conditions dictate the production of… (More)
DOI: 10.1126/sciimmunol.aah4609

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Cite this paper

@article{Sanford2016InhibitionOH, title={Inhibition of HDAC8 and HDAC9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to TLR ligands.}, author={James A. Sanford and Ling-juan Zhang and Michael R. Williams and Jon A. Gangoiti and Chun-Ming Huang and Richard L Gallo}, journal={Science immunology}, year={2016}, volume={1 4} }