Inhibition of HCV replicon cell growth by 2-arylbenzofuran derivatives isolated from Mori Cortex Radicis.

@article{Lee2007InhibitionOH,
  title={Inhibition of HCV replicon cell growth by 2-arylbenzofuran derivatives isolated from Mori Cortex Radicis.},
  author={Hyun Yong Lee and Ji Hyun Yum and Yang Kook Rho and Seong Jun Oh and Hyun Sik Choi and Hwan Bong Chang and Dong Hwa Choi and M J Leem and Eun Joo Choi and Jei Man Ryu and Soon Bong Hwang},
  journal={Planta medica},
  year={2007},
  volume={73 14},
  pages={1481-5}
}
Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection. In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the methanol extract of Mori Cortex Radicis was selected. Fractionation of the extract by monitoring antiviral activity with a replicon cell-based assay resulted in the isolation of five… CONTINUE READING