Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis.

  title={Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis.},
  author={Marlene Kr{\"a}mer and Clara Dees and Jingang Huang and Inga Schlottmann and Katrin Palumbo-Zerr and Pawel Zerr and K Gelse and Christian Beyer and Alfiya Distler and Victor E. Marquez and Oliver Distler and Georg Schett and J{\"o}rg H. W. Distler},
  journal={Annals of the rheumatic diseases},
  volume={72 4},
OBJECTIVES Epigenetic modifications such as DNA methylation and histone acetylation have been implicated in the pathogenesis of systemic sclerosis. However, histone methylation has not been investigated so far. We therefore aimed to evaluate the role of the trimethylation of histone H3 on lysine 27 (H3K27me3) on fibroblast activation and fibrosis. METHODS H3K27me3 was inhibited by 3-deazaneplanocin A (DZNep) in cultured fibroblasts and in two murine models of dermal fibrosis. Fibrosis was… CONTINUE READING


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