Inhibition of Gonadotrophin by a Highly Purified Pineal Peptide and by Synthetic Arginine Vasotocin

@article{Pavel1966InhibitionOG,
  title={Inhibition of Gonadotrophin by a Highly Purified Pineal Peptide and by Synthetic Arginine Vasotocin},
  author={Sandy Pavel and S T Petrescu},
  journal={Nature},
  year={1966},
  volume={212},
  pages={1054-1054}
}
THERE is evidence in the literature which suggests that the pineal gland is capable of inhibiting the action of gonadotrophin1–5, but the principle involved has not been identified or characterized. Wurtman et al.6,7 demonstrated that melatonin reduces the weight of the ovary and decreases the incidence of oestrus in rats, and Chu et al.8 have reported an anti-oestrus effect of melatonin in both rats and mice, but Ebels and Prop9 were not able to influence gonadal weight or the oestrous cycle… CONTINUE READING