Inhibition of Glutathione Synthesis Induced by Exhaustive Running Exercise via the Decreased Influx Rate of L-Cysteine in Rat Erythrocytes

@article{Xiong2016InhibitionOG,
  title={Inhibition of Glutathione Synthesis Induced by Exhaustive Running Exercise via the Decreased Influx Rate of L-Cysteine in Rat Erythrocytes},
  author={Yanlian Xiong and Y. Xiong and Shuai Zhou and Zhen-hai Yu and Dong-mei Zhao and Zhiqiang Wang and Yuling Li and Jingtong Yan and Yueting Cai and Wenqian Zhang},
  journal={Cellular Physiology and Biochemistry},
  year={2016},
  volume={40},
  pages={1410 - 1421}
}
Background/Aims: The main purpose of this study was to investigate the effect of exhaustive exercise on L-cysteine uptake and its effect on erythrocyte glutathione (GSH) synthesis and metabolism. Methods: Rats were divided into three groups: sedentary control (C), exhaustive running exercise (ERE) and moderate running exercise (MRE) (n=12 rats/group). We determined the L-cysteine efflux and influx in vitro in rat erythrocytes and its relationship with GSH synthesis. Total anti-oxidant potential… Expand
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References

SHOWING 1-10 OF 51 REFERENCES
L-cysteine efflux in erythrocytes as a function of human age: correlation with reduced glutathione and total anti-oxidant potential.
TLDR
A significant (p<0.0001) decline in the efflux of L-cysteine in erythrocytes during human aging, and the GSH/GSSG ratio decreases as a function of human age, correlates with the decrease in GSH and the FRAP value. Expand
Changes in blood lipid peroxidation markers and antioxidants after a single sprint anaerobic exercise
TLDR
It is demonstrated that short-term supramaximal anaerobic exercise induces an oxidative stress and that the plasma TBARS level is not a suitable marker during this type of exercise. Expand
L-cysteine influx in erythrocytes as a function of human age.
TLDR
A significant decline in the influx of L-cysteine in erythrocytes during aging in humans is shown and the decrease correlates with the decrease in antioxidant potential of plasma measured in terms of FRAP (ferric-reducing ability of plasma) during aging. Expand
Glutathione homeostasis in response to exercise training and nutritional supplements
  • C. Sen
  • Biology, Medicine
  • Molecular and Cellular Biochemistry
  • 2004
TLDR
Results show that sprint training may also have a beneficial effect on tissue GSH homeostasis against exercise induced oxidative stress and an improved form of LA, a positively charged analogue (LA-Plus), has been discovered. Expand
l-Cysteine influx and efflux: A possible role for red blood cells in regulation of redox status of the plasma
TLDR
It could be concluded that erythrocytes play a role in the regulation of the plasma redox status and intracellular level of GSH determines the rate of the l-cysteine efflux. Expand
[L-cysteine influx in diabetic erythrocytes].
TLDR
The L-cysteine influx in erythrocytes from type 2 diabetic patients was significantly lower compared to age-matched controls, and this decreased influx may be one of the factors leading to low GSH concentration observed in type 2 diabetes. Expand
Exhaustive Running Exercise Induce Tyrosine Phosphorylation of Band 3 in Rat Erythrocytes
TLDR
It appears that exhaustive running exercise induced band 3 phosphorylation is due to the oxidation of critical sulfydryl groups of a membrane phosphatase (PTP) and alters band-3 membrane organization. Expand
Oxidative stress, exercise, and antioxidant supplementation.
TLDR
This review examines the markers used to determine oxidative stress in blood and muscle samples, the changes in oxidative stress markers induced by exercise, and whether athletes require antioxidant supplements. Expand
Toxicity of low levels of methylglyoxal: depletion of blood glutathione and adverse effect on glucose tolerance in mice.
TLDR
Chronic intake of methylglyoxal, at levels that could be attained in food, is toxic by depletion of blood GSH and could have adverse effect on some GSH dependent functions in vivo. Expand
Age-Related Changes on Glucose Transport and Utilization of Human Erythrocytes: Effect of Oxidative Stress
TLDR
An age-related decrease in the both glucose transport and utilization in erythrocytes is indicated, which is associated with an impairment in glucose homeostasis. Expand
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5
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