Inhibition of Glutathione Synthesis Induced by Exhaustive Running Exercise via the Decreased Influx Rate of L-Cysteine in Rat Erythrocytes

  title={Inhibition of Glutathione Synthesis Induced by Exhaustive Running Exercise via the Decreased Influx Rate of L-Cysteine in Rat Erythrocytes},
  author={Yanlian Xiong and Y. Xiong and Shuai Zhou and Zhen-hai Yu and Dong-mei Zhao and Zhiqiang Wang and Yuling Li and Jingtong Yan and Yueting Cai and Wenqian Zhang},
  journal={Cellular Physiology and Biochemistry},
  pages={1410 - 1421}
Background/Aims: The main purpose of this study was to investigate the effect of exhaustive exercise on L-cysteine uptake and its effect on erythrocyte glutathione (GSH) synthesis and metabolism. Methods: Rats were divided into three groups: sedentary control (C), exhaustive running exercise (ERE) and moderate running exercise (MRE) (n=12 rats/group). We determined the L-cysteine efflux and influx in vitro in rat erythrocytes and its relationship with GSH synthesis. Total anti-oxidant potential… Expand
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