Inhibition of Glucose Transport by Tomatoside A, a Tomato Seed Steroidal Saponin, through the Suppression of GLUT2 Expression in Caco-2 Cells.

@article{Li2018InhibitionOG,
  title={Inhibition of Glucose Transport by Tomatoside A, a Tomato Seed Steroidal Saponin, through the Suppression of GLUT2 Expression in Caco-2 Cells.},
  author={Bao-Qin Li and Yusuke Terazono and N. Hirasaki and Yuki Tatemichi and E. Kinoshita and A. Obata and T. Matsui},
  journal={Journal of agricultural and food chemistry},
  year={2018},
  volume={66 6},
  pages={
          1428-1434
        }
}
We investigated whether tomatoside A (5α-furostane-3β,22,26-triol-3-[O-β-d-glucopyranosyl (1→2)-β-d-glucopyranosyl (1→4)-β-d-galactopyranoside] 26-O-β-d-glucopyranoside), a tomato seed saponin, may play a role in the regulation of intestinal glucose transport in human intestinal Caco-2 cells. Tomatoside A could not penetrate through Caco-2 cell monolayers, as observed in the transport experiments using liquid chromatography-mass spectrometry. The treatment of cells with 10 μM tomatoside A for 3… Expand
Intestinal Saturated Long-Chain Fatty Acid, Glucose and Fructose Transporters and Their Inhibition by Natural Plant Extracts in Caco-2 Cells
TLDR
This review summarizes the knowledge about binding sites of named transporters and lists the plant extracts which were tested in Caco-2 cells regarding uptake inhibition and the largest part of active components in plant extracts belongs to the group of polyphenols. Expand
In Vitro Bioaccessibility of Extractable Compounds from Tannat Grape Skin Possessing Health Promoting Properties with Potential to Reduce the Risk of Diabetes
TLDR
The bioaccessible compounds of the extract, including phenols, modulated key biochemical events involved in the pathogenesis of diabetes such as oxidative stress, inflammation and glucose absorption, supporting its potential for either reducing the risk or treating this disease. Expand
Number of galloyl moieties and molecular flexibility are both important in alpha-amylase inhibition by galloyl-based polyphenols.
TLDR
The hypoglycemic effects of two polyphenols with 5 free GMs indicate that GMs may be considered a functional fragment involved in the alleviation of the symptoms of type II diabetes through α-amylase inhibition. Expand
Theaflavins inhibit glucose transport across Caco-2 cells through the downregulation of the Ca2+/AMP-activated protein kinase-mediated glucose transporter SGLT1
Abstract The study investigated the effects of theaflavins, which are intestinally non-absorbable compounds, on intestinal glucose transport in Caco-2 cells. 13C6-Glucose transport experimentsExpand
New insights into potential nutritional effects of dietary saponins in protecting against the development of obesity.
TLDR
Dietary saponin have been approved as potent pancreatic lipase inhibitors, disaccharidase enzyme inhibitors, antagonistic to in vitro lipogenesis and in vivo appetite suppressants, antioxidants, immune-regulators, prevent fatty liver formation, protects epithelial vasculature and regulate body weight. Expand
Ethanolic Extract of Caesalpinia Bonducella f. Seed Ameliorates Diabetes Phenotype of Streptozotocin-Nicotinamide-Induced Type 2 Diabetes Rat
TLDR
Seed Ameliorates Diabetes Phenotype of StreptozotocinNicotinamide-Induced Type 2 Diabetes Rat and Ethanolic Extract of Caesalpinia bonducella f. Expand