Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents.

@article{Shakoori2007InhibitionOG,
  title={Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents.},
  author={Abbas Shakoori and W. Mai and Katsuyoshi Miyashita and Kazuo Yasumoto and Yutaka Takahashi and Akishi Ooi and Kazuyuki Kawakami and Toshinari Minamoto},
  journal={Cancer science},
  year={2007},
  volume={98 9},
  pages={
          1388-93
        }
}
The authors' recent discovery that glycogen synthase kinase-3beta (GSK-3beta) participates in colon cancer cells' survival and proliferation prompted us to investigate whether GSK-3beta inhibition alters proliferation of colon cancer cells in vivo. Groups of four or five athymic mice (Balb/c, nu/nu) with subcutaneous xenografts of SW480 human colon cancer cells were treated with dimethyl sulfoxide (DMSO) or different doses (1, 2 and 5 mg/kg body weight) of either small-molecule GSK-3beta… CONTINUE READING
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