Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells

@article{Desch2010InhibitionOG,
  title={Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells},
  author={Petra Desch and Daniela Asslaber and Daniela Kern and Harald Schnidar and Doris Mangelberger and Beate Alinger and Markus Stoecher and Sebastian W. Hofbauer and Daniel Neureiter and Ingeborg Tinhofer and Fritz Aberger and Tanja Nicole Hartmann and Richard Greil},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={4885-4895}
}
The Hedgehog (Hh) pathway regulates cell proliferation and survival and contributes to tumorigenesis. We investigated the expression and function of this pathway in B-cell chronic lymphocytic leukemia (CLL) cells and in healthy B lymphocytes. Profiling of cognate Hh pathway members revealed reduced expression of two key Hh signaling effectors, Smoothened (SMOH) and GLI, in CLL cells, whereas transcription levels of other investigated members resembled normal B-lymphocyte levels. Examining the… CONTINUE READING
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