Inhibition of GABA transaminase enhances light-induced circadian phase delays but not advances.

@article{Golombek1994InhibitionOG,
  title={Inhibition of GABA transaminase enhances light-induced circadian phase delays but not advances.},
  author={Diego Andr{\'e}s Golombek and Martin Roland Ralph},
  journal={Journal of biological rhythms},
  year={1994},
  volume={9 3-4},
  pages={251-61}
}
The CNS neurotransmitter GABA is distributed extensively throughout the suprachiasmatic nucleus, the site of circadian pacemaker cells in mammals. Pharmacological agents that act at GABAA receptors alter specific circadian responses to light and may induce phase shifts of circadian rhythms. In the present study, the role of endogenously released GABA in rhythm regulation was investigated using vigabatrin (gamma-vinyl GABA), an agent that has been shown to increase chronically or acutely the CNS… CONTINUE READING