• DOI:10.3181/00379727-177-41961
Corpus ID: 43578659

Inhibition of Furosemide-Induced Kaliuresis in the Rat by Trilostane, an Inhibitor of Adrenal Steroidogenesis

@article{Harding1984InhibitionOF,
  title={Inhibition of Furosemide-Induced Kaliuresis in the Rat by Trilostane, an Inhibitor of Adrenal Steroidogenesis},
  author={H. R. Harding and J. Creange and G. O. Potts and H. P. Schane},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1984},
  volume={177},
  pages={388 - 391}
}

H. R. Harding, J. Creange, +1 author H. P. Schane

Published 1984

Chemistry, Medicine

Proceedings of the Society for Experimental Biology and Medicine

Abstract In rats treated with furosemide, urinary losses of water, sodium and potassium were accompanied by increased circulating levels of aldosterone. Trilostane, an inhibitor of adrenal 3β-hydroxysteroid dehydrogenase activity, prevented furosemide-induced hyperaldosteronism which resulted in a partial inhibition of diuretic-induced kaliuresis without a change in sodium and water excretion. Spironolactone, an antagonist of mineralocorticoid action with inherent diuretic activity, produced… CONTINUE READING

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