Inhibition of Furosemide-Induced Kaliuresis in the Rat by Trilostane, an Inhibitor of Adrenal Steroidogenesis

@article{Harding1984InhibitionOF,
  title={Inhibition of Furosemide-Induced Kaliuresis in the Rat by Trilostane, an Inhibitor of Adrenal Steroidogenesis},
  author={H. R. Harding and J. Creange and G. O. Potts and H. P. Schane},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1984},
  volume={177},
  pages={388 - 391}
}
  • H. R. Harding, J. Creange, +1 author H. P. Schane
  • Published 1984
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine
  • Abstract In rats treated with furosemide, urinary losses of water, sodium and potassium were accompanied by increased circulating levels of aldosterone. Trilostane, an inhibitor of adrenal 3β-hydroxysteroid dehydrogenase activity, prevented furosemide-induced hyperaldosteronism which resulted in a partial inhibition of diuretic-induced kaliuresis without a change in sodium and water excretion. Spironolactone, an antagonist of mineralocorticoid action with inherent diuretic activity, produced… CONTINUE READING
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