Inhibition of Furine Ribonucleotide and Phosphoribosyl Pyrophosphate Synthesis by 6-CycIopentylthio-9- hydroxymethylpurine and Structurally Related Compounds1

Abstract

o-Cyclopentylthio-Q-hydroxymethylpurine, 9-(3-aminopropyl)adenine, and structurally related compounds in hibited the conversion of adenine, guanine, and hypoxanthine to ribonucleotides in Ehrlich ascites tumor cells in vitro. These compounds also inhibited the accumulation of phosphoribosyl pyrophosphate, a substrate required for ribonucleotide formation from purines. 6-Cyclopentylthio9-hydroxymethylpurine inhibits the growth of cultured human leukemic cells.

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Cite this paper

@inproceedings{Smith2006InhibitionOF, title={Inhibition of Furine Ribonucleotide and Phosphoribosyl Pyrophosphate Synthesis by 6-CycIopentylthio-9- hydroxymethylpurine and Structurally Related Compounds1}, author={Camilla M. Smith and Lydia J. Fontanelle and Marcel Lalanne and Frank Henderson}, year={2006} }