Purification and Properties of Adenosine Kinase from Human Tumor Cells
- H. P. Schnebli, Hill, D. L, L. L. Bennett, Jr.
- Type H. Ep. No. 2. J. Biol. Chem.,
o-Cyclopentylthio-Q-hydroxymethylpurine, 9-(3-aminopropyl)adenine, and structurally related compounds in hibited the conversion of adenine, guanine, and hypoxanthine to ribonucleotides in Ehrlich ascites tumor cells in vitro. These compounds also inhibited the accumulation of phosphoribosyl pyrophosphate, a substrate required for ribonucleotide formation from purines. 6-Cyclopentylthio9-hydroxymethylpurine inhibits the growth of cultured human leukemic cells.