Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase

@inproceedings{Morfini2013InhibitionOF,
  title={Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase},
  author={Gerardo A Morfini and Daryl A. Bosco and Hannah R. Brown and Rodolfo G Gatto and Agnieszka Kaminska and Yuyu Song and Linda Molla and Lisa M. Baker and M. Natalia Marangoni and Sarah L Berth and Ehsan Tavassoli and Carolina Bagnato and Ashutosh Tiwari and Lawrence J. Hayward and Gustavo F Pigino and D Martin Watterson and Chun-Fang Huang and G. Banker and R. H. Brown and Scott T Brady},
  booktitle={PloS one},
  year={2013}
}
Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefined. Characteristics of motor neurons affected in FALS include abnormal kinase activation, aberrant neurofilament phosphorylation, and fast axonal transport (FAT) deficits, but functional relationships among these pathogenic events were unclear… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 90 references

APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 5 Excerpts
Highly Influenced

A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 4 Excerpts
Highly Influenced

Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.

Proceedings of the National Academy of Sciences of the United States of America • 2012
View 1 Excerpt

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