Inhibition of Experimental Seizures in Canines by Repetitive Vagal Stimulation

@article{Zabara1992InhibitionOE,
  title={Inhibition of Experimental Seizures in Canines by Repetitive Vagal Stimulation},
  author={Jacob Zabara},
  journal={Epilepsia},
  year={1992},
  volume={33}
}
  • J. Zabara
  • Published 1 November 1992
  • Biology, Medicine
  • Epilepsia
Summary: Repetitive electrical stimulation of the canine cervical vagus nerve interrupts or abolishes motor seizures induced by strychnine and tremors induced by pentylenetetrazol (PTZ). Tremors were defined as rhythmic alternating contractions of opposing muscle groups, exerting much less force than seizure contractions. Seizures were induced by injection boluses of strychnine or PTZ at 1‐ to 4‐min intervals until sustained muscle activity was observed electromyographically (EMG). Vagal… 

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References

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These results, when taken together with similar results obtained from dogs, monkeys, and humans, strongly suggest that periodic stimulation of the vagus nerve using appropriate stimulation parameters is a powerful method for preventing seizures.

Vagal Stimulation Reduces the Severity of Maximal Electroshock Seizures in Intact Rats: Use of a Cuff Electrode for Stimulating and Recording

Thai repetitive vagal stimulation (VS) prevents or ameliorates convulsive seizures in dogs and it is rational to test VS in man as a treatment for intractable seizures.

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