Inhibition of Experimental Seizures in Canines by Repetitive Vagal Stimulation

  title={Inhibition of Experimental Seizures in Canines by Repetitive Vagal Stimulation},
  author={Jacob Zabara},
  • J. Zabara
  • Published 1 November 1992
  • Biology, Medicine
  • Epilepsia
Summary: Repetitive electrical stimulation of the canine cervical vagus nerve interrupts or abolishes motor seizures induced by strychnine and tremors induced by pentylenetetrazol (PTZ). Tremors were defined as rhythmic alternating contractions of opposing muscle groups, exerting much less force than seizure contractions. Seizures were induced by injection boluses of strychnine or PTZ at 1‐ to 4‐min intervals until sustained muscle activity was observed electromyographically (EMG). Vagal… 

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