Inhibition of ERK1/2 activation by phenolic antioxidants protects kidney tubular cells during cold storage.

@article{Karhumki2007InhibitionOE,
  title={Inhibition of ERK1/2 activation by phenolic antioxidants protects kidney tubular cells during cold storage.},
  author={Paulina Karhum{\"a}ki and Sari L Tiitinen and Hannu Turpeinen and Jaakko Parkkinen},
  journal={Transplantation},
  year={2007},
  volume={83 7},
  pages={948-53}
}
BACKGROUND Cold storage of tissues induces reactive oxygen species (ROS), which contribute to cell injury. We have compared different antioxidants in protection of renal tubular cells against hypothermia injury and studied their effect on cold-induced mitogen-activated protein (MAP) kinase activation. METHODS Cultured renal tubular epithelial cells (LLC-PK1) were stored in University of Wisconsin solution supplemented with compounds tested for 16 hr at 4 degrees C. Release of lactate… CONTINUE READING

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