Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.

  title={Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.},
  author={C. Tang and S. Ranatunga and Crystina L. Kriss and C. Cubitt and J. Tao and J. Pinilla-Ibarz and Juan R Del Valle and C. Hu},
  journal={The Journal of clinical investigation},
  volume={124 6},
  • C. Tang, S. Ranatunga, +5 authors C. Hu
  • Published 2014
  • Biology, Medicine
  • The Journal of clinical investigation
  • Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER stress-associated transcription factor XBP-1 in B cells and found that XBP-1 deficiency decelerates malignant progression of CLL-associated disease. XBP-1 deficiency resulted in acquisition of phenotypes that are disadvantageous for leukemic cell survival, including compromised BCR signaling capability and increased surface… CONTINUE READING
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