Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.

  title={Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.},
  author={Hyun Jung Jun and Roderick Terry Bronson and Alain Charest},
  journal={Stem cells},
  volume={32 2},
Glioblastoma multiforme (GBM) is the most lethal form of primary brain tumors, characterized by highly invasive and aggressive tumors that are resistant to all current therapeutic options. GBMs are highly heterogeneous in nature and contain a small but highly tumorigenic and self-renewing population of stem or initiating cells (glioblastoma stem cells or GSCs). GSCs have been shown to contribute to tumor propagation and resistance to current therapeutic modalities. Recent studies of human GBMs… CONTINUE READING
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stem cells

  • J Acquaviva, HJ Jun, J Lessard
  • Neuro Oncol (2013);15:161–171
  • 2013

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