Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate.

Abstract

Acetylcholine hydrolysis by acetylcholinesterase is inhibited at high substrate concentrations. To determine the residues involved in this phenomenon, we have mutated most of the residues lining the active-site gorge but mutating these did not completely eliminate hydrolysis. Thus, we analyzed the effect of a nonhydrolysable substrate analogue on substrate… (More)

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@article{Stojan2004InhibitionOD, title={Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate.}, author={Jure Stojan and Laure Brochier and Carole Alies and Jacques Philippe Colletier and Didier D Fournier}, journal={European journal of biochemistry}, year={2004}, volume={271 7}, pages={1364-71} }