Inhibition of Delta-Like Ligand 4 Induces Luteal Hypervascularization Followed by Functional and Structural Luteolysis in the Primate Ovary

@inproceedings{Fraser2012InhibitionOD,
  title={Inhibition of Delta-Like Ligand 4 Induces Luteal Hypervascularization Followed by Functional and Structural Luteolysis in the Primate Ovary},
  author={Hamish M. Fraser and Julie M. Hastings and Deborah Allan and Keith D. Morris and John S. Rudge and Stanley J. Wiegand},
  booktitle={Endocrinology},
  year={2012}
}
Using specific inhibitors established that angiogenesis in the ovarian follicle and corpus luteum is driven by vascular endothelial growth factor. Recently, it has been demonstrated that the Notch ligand, delta-like ligand 4 (Dll4) negatively regulates vascular endothelial growth factor-mediated vessel sprouting and branching. To investigate the role of Dll4 in regulation of the ovarian vasculature, we administered a neutralizing antibody to Dll4 to marmosets at the periovulatory period. The… CONTINUE READING