Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis.

Abstract

Thirteen lignans, erythro-austrobailignan-6 (1), meso-dihydroguaiaretic acid (2), sauchinone (3), 1'-epi-sauchinone (4), saucerneol D (5), manassantin B (6), manassantin A (7), nectandrin B (8), machilin D (9), saucerneol F (10), saucerneol G (11), saucerneol H (12) and saucerneol I (13), were isolated from the ethyl acetate extract of the roots of Saururus chinensis. Among these compounds, 5 showed potent inhibitory activities against DNA topoisomerase I and II, and 5, 6, 7 and 10 showed mild cytotoxicities against HT-29 (IC(50) values; 13, 12, 11, and 10 microM, respectively) and HepG2 cell lines (IC(50) values; 16, 11, 12, and 11 microM, respectively).

DOI: 10.1007/s12272-009-2010-7

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Cite this paper

@article{Lee2009InhibitionOD, title={Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis.}, author={Yeun-Kyung Lee and Chang-seob Seo and Chong-soon Lee and Kyong-Seon Lee and Shin-Jung Kang and Yurngdong Jahng and Hyun Wook Chang and Jong-Keun Son}, journal={Archives of pharmacal research}, year={2009}, volume={32 10}, pages={1409-15} }