Corpus ID: 8718343

Inhibition of DNA polymerase eta by oxetanocin derivatives.

  title={Inhibition of DNA polymerase eta by oxetanocin derivatives.},
  author={S. Izuta},
  journal={Nucleic acids symposium series},
  • S. Izuta
  • Published 2006
  • Medicine
  • Nucleic acids symposium series
DNA polymerase eta is recently found as a responsible gene product of xeroderma pigmentosum variant. Differently from other eukaryotic DNA polymerases, such as alpha, beta or gamma, eta polymerase is categorized in Y family. Specific inhibitors for DNA polymerases are useful tools to study the exact role of enzyme in the living cells, however, the inhibitor for DNA polymerase eta has not been developed. We examined the inhibitory effects of several sugar-modified nucleotide analogs on DNA… Expand
Translesion DNA synthesis in the context of cancer research
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