• Corpus ID: 6060679

Inhibition of DNA polymerase-alpha from rat hepatoma with a series of new synthetic polynucleotides.

@article{Li1983InhibitionOD,
  title={Inhibition of DNA polymerase-alpha from rat hepatoma with a series of new synthetic polynucleotides.},
  author={Zhong Rong Li and Y. K. Ho and Thomas J. Bardos},
  journal={Cancer biochemistry biophysics},
  year={1983},
  volume={6 4},
  pages={
          221-8
        }
}
In continuation of efforts to correlate the antitemplate activities of chemically modified polynucleotides with their base composition and structure, four synthetic copolymers, poly(A,C), poly(C,U), poly(A,C,U), and poly(A,C,G) were modified by thiolation of 2.6-4.8% of their pyrimidine bases. The resulting 5-mercaptoheteropolynucleotides and the previously described 5-mercapto-polycytidylate (MPC) and -polyuridylate (MPU) were tested in a comparative manner as inhibitors of the DNA polymerase…