Inhibition of DNA methyltransferases regulates cocaine self-administration by rats: a genome-wide DNA methylation study.

@article{Fonteneau2017InhibitionOD,
  title={Inhibition of DNA methyltransferases regulates cocaine self-administration by rats: a genome-wide DNA methylation study.},
  author={Mathieu Fonteneau and Dominique Filliol and Patrick Anglard and Katia Befort and Pascal Romieu and Jean Zwiller},
  journal={Genes, brain, and behavior},
  year={2017},
  volume={16 3},
  pages={313-327}
}
DNA methylation is a major epigenetic process which regulates the accessibility of genes to the transcriptional machinery. In the present study, we investigated whether modifying the global DNA methylation pattern in the brain would alter cocaine intake by rats, using the cocaine self-administration test. The data indicate that treatment of rats with the DNA methyltransferase inhibitors 5-aza-2'-deoxycytidine (dAZA) and zebularine enhanced the reinforcing properties of cocaine. To obtain some… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS