Inhibition of DNA methyltransferase by microbial inhibitors and fatty acids.

@article{Suzuki1996InhibitionOD,
  title={Inhibition of DNA methyltransferase by microbial inhibitors and fatty acids.},
  author={K. Suzuki and K. Nagao and J. Tokunaga and N. Katayama and M. Uyeda},
  journal={Journal of enzyme inhibition},
  year={1996},
  volume={10 4},
  pages={
          271-280
        }
}
Streptomyces sp. strain No. 560 produces four kinds of DNA methyltransferase inhibitors in the culture filtrate. One of them, DMI-4 was distinguished from DMI-1, -2 and -3 previously reported with respect to certain properties, DMI-4 is considered to be a triglyceride consisting of the fatty acids anteisopentadecanoic acid (C15:0), isopalmitic acid (C16:0) and isostearic acid (C18:0) from the results of gas chromatography analysis. Since DMI-4 contains three molecules of fatty acid, and the… Expand
Daucus carota Cells Contain Specific DNA Methyltransferase Inhibitors that Interfere with Somatic Embryogenesis
TLDR
Results of chemical analyses indicate that the inhibitors differ from lipidic inhibitors described in Escherichia coli and Streptomyces sp. Expand
Inhibition of Topoisomerases by Fatty Acids
TLDR
Petroselinic acid was a topoisomerase inhibitor of the cleavable complex-nonforming type and acted directly on the enzyme molecule in a noncompetitive manner without DNA intercalation. Expand
[Metabolites produced by actinomycetes--antiviral antibiotics and enzyme inhibitors].
  • M. Uyeda
  • Chemistry, Medicine
  • Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2004
TLDR
Using bacitracin-resistant strains, enhanced and astringent production of fattiviracin was achieved, and FV-13, which has the longest fatty acid chains in the molecule, was dramatically enhanced by a C(55)-isoprenyl phosphate metabolism. Expand
1513-DMIa and 1513-DMIb, DNA methyltransferase inhibitors produced by Streptomyces sp. strain No. 1513.
Two new methyltransferase inhibitors were isolated from the culture filtrate of Streptomyces sp. strain No. 1513 and named 1513-DMIa and 1513-DMIb. 1513-DMIa and 1513-DMIb were distinguished inExpand
Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520. I. Taxonomy, fermentation, isolation and biological activities.
TLDR
A novel inhibitor of topoisomerases designated as topostatin was isolated from the culture filtrate of Thermomonospora alba strain No. 1520, but did not exhibit any antimicrobial activity against Gram-positive and Gram-negative bacteria, yeasts and fungi. Expand
Advances in the Chemistry of Natural and Semisynthetic Topoisomerase I/II Inhibitors
Abstract The search for new, effective, and low-toxic anticancer agents is one of the most important tasks of modern medicinal chemistry. In general, the solution to this problem comes down toExpand
A new stereoselective synthesis of biologically active di- and trienoic acids containing a (1Z,5Z)-diene moiety
Natural (5Z,9Z)-dienoic acids and key precursors of biologically active trienoic acids were prepared in high yields and with high stereoselectivity using cross-cyclomagnesiation of terminal andExpand
Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD
TLDR
After a recovery period of 1 week of no treatment, these animals exhibited normal spatial reversal learning indicating that the behavioral cognitive deficits caused by PPA seem to be reversible. Expand
Examining the non-spatial pretraining effect on a water maze spatial learning task in rats treated with multiple intracerebroventricular (ICV) infusions of propionic acid: Contributions to a rodent model of ASD
TLDR
PPA treated rats failed to show the positive effects of the non-spatial pretraining procedure, relative to controls, as evidenced by increased search latencies, longer distances travelled, fewer direct and circle swims, and more time spent in the periphery of the maze than PBS controls. Expand

References

SHOWING 1-10 OF 18 REFERENCES
DMI-1, a new DNA methyltransferase inhibitor produced by Streptomyces sp. strain No. 560.
TLDR
DMI-1 is a novel inhibitor of methyltransferase isolated from microorganisms and is structurally different from sinefungin and A9145C which are structural analogs of S-adenosylmethionine (methyl donor). Expand
Identification of a critical cysteine in EcoRI DNA methyltransferase by mass spectrometry.
TLDR
N-ethylmaleimide modification of Cys-223 in EcoRI DNA MTase is responsible for the loss of enzyme activity, supported by the similarity of the reactions catalyzed by adenine N-6 and cytosines N-4 DNA MTases, the frequent presence of Asn-flanking Cys, and the importance of CYS-223 to EcoRI MTase function. Expand
Inhibition of EcoRI DNA methylase with cofactor analogs.
TLDR
Gel retardation assays confirm that the methylase-DNA-sinefungin complex is sequence-specific, and the ternary complex is the first sequence- specific complex detected for any DNA methylase. Expand
The antifungal antibiotic sinefungin as a very active inhibitor of methyltransferases and of the transformation of chick embryo fibroblasts by Rous sarcoma virus.
TLDR
Sinefungin, like SAH and SIBA, is a competitive inhibitor in vitro of tRNA methylases and of protein methylases I and III of CEF, and is in vitro the most active t RNA methylase inhibitor described until now. Expand
Sequence-specific BamHI methylase. Purification and characterization.
TLDR
Studies on the mechanism of methylation indicate that both strands of the recognition sequence are modified in a single binding event, and the sequence specificity of the methylase is relaxed upon the addition of glycerol in the reaction mixture. Expand
Structural and functional analysis of EcoRI DNA methyltransferase by proteolysis.
TLDR
The results suggest the Mtase is a two-domain protein connected by a highly flexible interdomain hinge that undergoes significant conformational changes upon ligand binding as well as the generation of similar fragments with SV8 endoprotease which has entirely different peptide specificities. Expand
Fatty acids inhibit N-methylation of phosphatidylethanolamine in rat hepatocytes and liver microsomes.
TLDR
While fatty acids stimulate phosphatidylcholine biosynthesis in hepatocytes via the CDP-choline pathway, the methylation pathway is inhibited. Expand
A9145, a new adenine-containing antifungal antibiotic. I. Discovery and isolation.
TLDR
A9145 is a new water-soluble antifungal antibiotic produced by a strain of Streptomyces griseolus (NRRL 3739) that contains adenine and a possible sugar moiety, and forms crystalline organic and inorganic salts. Expand
CRYSTALLINE DESOXYRIBONUCLEASE: I. ISOLATION AND GENERAL PROPERTIES SPECTROPHOTOMETRIC METHOD FOR THE MEASUREMENT OF DESOXYRIBONUCLEASE ACTIVITY
A crystalline enzyme capable of digesting thymus nucleic acid (desoxyribonucleic acid) has been isolated from fresh beef pancreas. The enzyme called "desoxyribonuclease" is a protein of the albuminExpand
A specific endonuclease from Arthrobacter luteus.
TLDR
This enzyme cleaves bacteriophage λ DNA, adenovirus-2 DNA and simian virus 40 DNA at many sites including all sites cleaved by the endonuclease Hind III from Haemophilus influenzae serotype d. Expand
...
1
2
...