Inhibition of DNA binding of Sox2 by the SUMO conjugation.

@article{Tsuruzoe2006InhibitionOD,
  title={Inhibition of DNA binding of Sox2 by the SUMO conjugation.},
  author={Shu Tsuruzoe and Ko Ishihara and Yasuhiro Uchimura and Sugiko Watanabe and Yoko Sekita and Takahiro Aoto and Hisato Saitoh and Yasuhito Yuasa and Hitoshi Niwa and Michio Kawasuji and Hideo Baba and Mitsuyoshi Nakao},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={351 4},
  pages={
          920-6
        }
}
Sox2 is a member of the high mobility group (HMG) domain DNA-binding proteins for transcriptional control and chromatin architecture. The HMG domain of Sox2 binds the DNA to facilitate transactivation by the cooperative transcription factors such as Oct3/4. We report that mouse Sox2 is modified by SUMO at lysine 247. Substitution of the target lysine to arginine lost the sumoylation but little affected transcriptional potential or nuclear localization of Sox2. By contrast with the unmodified… CONTINUE READING

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