Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation

@inproceedings{Yang2015InhibitionOD,
  title={Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation},
  author={Lina Yang and Yuanyuan Liu and Chao Sun and Xinrui Yang and Zhen Yang and Juntao Ran and Qiuning Zhang and Hong Zhang and Xinyu Wang and XiaoHu Wang},
  booktitle={Oncology letters},
  year={2015}
}
Non-small cell lung cancer (NSCLC) exhibits radioresistance to conventional rays, due to its DNA damage repair systems. NSCLC may potentially be sensitized to radiation treatment by reducing those factors that continuously enhance the repair of damaged DNA. In the present study, normal lung fibroblast MRC-5 and lung cancer A549 cells were treated with NU7026 and CGK733, which are inhibitors of the DNA-dependent protein kinase catalytic subunit (PKcs) and ataxia telangiectasia mutated (ATM) and… CONTINUE READING

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