Inhibition of DC-SIGN-mediated HIV infection by a linear trimannoside mimic in a tetravalent presentation.

@article{Sattin2010InhibitionOD,
  title={Inhibition of DC-SIGN-mediated HIV infection by a linear trimannoside mimic in a tetravalent presentation.},
  author={Sara Sattin and Anna Daghetti and Michel Th{\'e}paut and Angela Berzi and Macarena S{\'a}nchez-Navarro and Georges Tabarani and Javier Rojo and Franck Fieschi and Mario Clerici and Anna Bernardi},
  journal={ACS chemical biology},
  year={2010},
  volume={5 3},
  pages={301-12}
}
HIV infection is pandemic in humans and is responsible for millions of deaths every year. The discovery of new cellular targets that can be used to prevent the infection process represents a new opportunity for developing more effective antiviral drugs. In this context, dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN), a lectin expressed at the surface of immature dendritic cells and involved in the initial stages of HIV infection, is a promising therapeutic target. Herein we show… CONTINUE READING

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