Inhibition of Cyclic GMP Export by Multidrug Resistance Protein 4: A New Strategy to Treat Erectile Dysfunction?

@article{Boydens2017InhibitionOC,
  title={Inhibition of Cyclic GMP Export by Multidrug Resistance Protein 4: A New Strategy to Treat Erectile Dysfunction?},
  author={Charlotte Boydens and Bart Pauwels and Laura Vanden Daele and Johan van de Voorde},
  journal={The journal of sexual medicine},
  year={2017},
  volume={14 4},
  pages={
          502-509
        }
}
BACKGROUND Intracellular cyclic guanosine monophosphate (cGMP) concentrations are regulated by degradation enzymes (phosphodiesterases) and by active transport across the plasma membrane by multidrug resistance proteins (MRPs) 4 and 5. AIM To evaluate the functional effect of MRP-4 inhibition and the role of MRP-4-mediated cGMP export in mouse corpora cavernosa. METHODS Isometric tension of mouse corpora cavernosa was measured after cumulative addition of MK-571, an inhibitor of MRP-4, or… CONTINUE READING

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