Inhibition of Corneal Inflammation by the Resolvin E1.

  title={Inhibition of Corneal Inflammation by the Resolvin E1.},
  author={Ji-Eun Lee and Yan Sun and Per Gjorstrup and Eric Pearlman},
  journal={Investigative ophthalmology & visual science},
  volume={56 4},
PURPOSE To investigate the role of the lipid mediator, resolvin E1 (RvE1), in corneal inflammation. METHODS The effect of RvE1 on stimulated human corneal epithelial cells (HCECs) and neutrophils, and mouse macrophage was assessed. C57BL/6 mouse corneas were abraded and treated with RvE1 either before or after stimulation with lipopolysaccharide (LPS) and antibiotic-killed Pseudomonas aeruginosa and Staphylococcus aureus. The levels of CXC chemokines in the cornea were quantified, and the… CONTINUE READING
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