Inhibition of Closure of the Ductus Arteriosus

  title={Inhibition of Closure of the Ductus Arteriosus},
  author={Jeffrey B Lakier and Michael A. Heymann and Abraham M. Rudolph},
  journal={Pediatric Research},
In many congenital cardiac lesions postnatal survival is dependent on ductus arteriosus(DA)patency. We studied a method for maintaining DA patency in lambs by formalin injection into its wall. In 10 late gestation fetal lambs, left thoracotomy was performed and 0.5-1.0 ml colored 10% formalin injected sub-adventitially along the ductal length; a pulmonary artery(PA) catheter was placed. 8 fetuses survived operation and delivered alive. Postnatally, catheters were placed in left ventricle… CONTINUE READING