Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF

@inproceedings{Jiang2016InhibitionOC,
  title={Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF},
  author={Xinni Jiang and Mengmeng Niu and Deshi Chen and Jing Chen and Yang Cao and Xiaorong Li and Haoqiang Ying and Johann S Bergholz and Yujun Zhang and Zhi-xiong Xiao},
  booktitle={Oncotarget},
  year={2016}
}
The adaptor protein Mig-6 is a negative regulator of EGF signaling. It is shown that Mig-6 inhibits cell migration via direct interaction with the ErbB receptors, thereby inhibiting cross-phosphorylation or targeting the receptors for degradation. Mig-6 has also been shown to bind to and inhibit the Rho GTPase Cdc42 to suppress cytoskeletal rearrangement. However, the molecular mechanism(s) by which Mig-6 inhibits cell migration via Cdc42 is still not entirely clear. Here, we show that Mig-6… CONTINUE READING
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