Inhibition of Candida parapsilosis mitochondrial respiratory pathways enhances susceptibility to caspofungin.

@article{Chamilos2006InhibitionOC,
  title={Inhibition of Candida parapsilosis mitochondrial respiratory pathways enhances susceptibility to caspofungin.},
  author={Georgios Chamilos and Russell E Lewis and Dimitrios P Kontoyiannis},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 2},
  pages={744-7}
}
Among the Candida species, Candida parapsilosis has a unique mitochondrial respiratory network. The addition of inhibitors of the respiratory pathways in three clinical isolates of C. parapsilosis with high (> or =2- microg/ml) MICs of caspofungin significantly (fivefold) decreased caspofungin MICs but did not change fluconazole MICs. 

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