Inhibition of Cancer Cell Proliferation and Metastasis by Insulin Receptor Downregulation

@inproceedings{Zhang2010InhibitionOC,
  title={Inhibition of Cancer Cell Proliferation and Metastasis by Insulin Receptor Downregulation},
  author={Hua Zhang and Dedra H Fagan and Xianke Zeng and Katie T. Freeman and Deepali Sachdev and Douglas Yee},
  booktitle={Oncogene},
  year={2010}
}
Insulin receptor (IR) and the type I IGF receptor (IGF1R) are structurally and functionally related. The function of IGF1R in cancer has been well documented and anti-IGF1R strategies to treat cancer have shown initial positive results. However, the role of IR in tumor biology, independent of IGF1R, is less clear. To address this issue, short hairpin RNA (shRNA) was used to specifically downregulate IR in two cancer cell lines, LCC6 and T47D. Cells with reduced IR showed reduced insulin… CONTINUE READING