Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1

@article{Rogers2003InhibitionOC,
  title={Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1},
  author={Candida Rogers and Vincenzina Reale and Kyuhyung Kim and Heather M Chatwin and Chris Cho-Pin Li and P. Evans and Mario de Bono},
  journal={Nature Neuroscience},
  year={2003},
  volume={6},
  pages={1178-1185}
}
Social and solitary feeding in natural Caenorhabditis elegans isolates are associated with two alleles of the orphan G-protein-coupled receptor (GPCR) NPR-1: social feeders contain NPR-1 215F, whereas solitary feeders contain NPR-1 215V. Here we identify FMRFamide-related neuropeptides (FaRPs) encoded by the flp-18 and flp-21 genes as NPR-1 ligands and show that these peptides can differentially activate the NPR-1 215F and NPR-1 215V receptors. Multicopy overexpression of flp-21 transformed… CONTINUE READING