Inhibition of Caco-2 and HeLa proliferation by Terminalia carpentariae C. T. White and Terminalia grandiflora Benth. extracts: Identification of triterpenoid components

@article{Courtney2017InhibitionOC,
  title={Inhibition of Caco-2 and HeLa proliferation by Terminalia carpentariae C. T. White and Terminalia grandiflora Benth. extracts: Identification of triterpenoid components},
  author={Reece Courtney and Joseph Sirdaarta and Alan David White and Ian Edwin Cock},
  journal={Polymer Journal},
  year={2017},
  volume={9},
  pages={441-451}
}
Background: Terminalia spp. are characterised by their high antioxidant capacities and many have anticancer activity. This study examines the anti-proliferative activity of T. carpentariae leaf and T. grandiflora leaf, fruit and nut extracts against Caco-2 and HeLa carcinoma proliferation. Materials and Methods: Powdered T. carpentariae leaf and T. grandiflora leaf, fruit and nut were extracted and tested for anti-proliferative activity against Caco-2 and HeLa cancer cell lines using… 

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References

SHOWING 1-10 OF 52 REFERENCES
Growth Inhibitory Activity of Kakadu Plum Extracts Against the Opportunistic Pathogenclostridium Perfringens: New Leads in the Prevention and Treatment of Clostridial Myonecrosis
Introduction: Clostridium perfringens is the etiological agent of clostridial myonecrosis and enteritis necroticans. Infections result in exotoxin production, tissue necrosis and unless promptly
The Anti-Proliferative Properties of Australian Plants with High Antioxidant Capacities Against Cancer Cell Lines
TLDR
The antiproliferative activity of the high antioxidant plant extracts against HeLa and CaCo 2 cancer cell lines indicates their potential in the treatment and prevention of some cancers.
Bacillus anthracis growth Inhibitory Properties of Australian Terminalia spp.: Putative Identification of low Polarity Volatile Components by GC-MS Headspace Analysis
Introduction: Anthrax is a severe acute disease caused by Bacillus anthracis infections. If untreated, it often results in mortality. Many Terminalia spp. have documented therapeutic properties as
Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents: doxorubicin and cisplatin against human hepatocellular carcinoma and lung cancer cells.
TLDR
The growth inhibitory activity of doxorubicin or cisplatin, as a single agent, may be modified by combinations of P. emblica or T. bellerica extracts and be synergistically enhanced in some cases.
An examination of the antibacterial, antifungal, anti-Giardial and anticancer properties of Kigelia africana fruit extracts
TLDR
Traditional African therapeutic usage of K. africana in the treatment of several bacterial, fungal and protozoal illnesses and some cancers is validated, and its use in treating a variety of diseases is validated.
Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis.
TLDR
Inotodiol inhibits cell proliferation through apoptosis induction by activating caspase-3 and partially inhibited the DNA fragmentation and growth-inhibition induced by inOTodiol.
GC-MS and LC-MS analysis of Kakadu plum fruit extracts displaying inhibitory activity against microbial triggers of multiple sclerosis
TLDR
The low toxicity of the T. ferdinandiana fruit extracts and their potent inhibitory bioactivity against the bacterial triggers of multiple sclerosis indicates their potential as medicinal agents in the treatment and prevention of this disease.
Evaluation of the potential of Macadamia integriflora extracts as antibacterial food agents
TLDR
The lack of toxicity of the M. integriflora extracts and their inhibitory bioactivity against a panel of bacteria and fungi demonstrate their potential as food additives to inhibit bacterial spoilage and food borne illnesses without the need for chemical preservative additives.
Assessment of the toxicity of selected Australian native plant extracts using the Artemia franciscana nauplii bioassay
TLDR
Thirty nine methanolic extracts from twenty five Australian native plants were investigated for toxicity using the Artemia franciscana nauplii lethality bioassay and compared to the reference toxins potassium dichromate and Mevinphos, confirming their potential for antibiotic usage.
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