Inhibition of Ca2+ inflow at nerve terminals of frog muscle blocks facilitation while phasic transmitter release is still considerable

@article{Dudel1990InhibitionOC,
  title={Inhibition of Ca2+ inflow at nerve terminals of frog muscle blocks facilitation while phasic transmitter release is still considerable},
  author={Josef Dudel},
  journal={Pfl{\"u}gers Archiv},
  year={1990},
  volume={415},
  pages={566-574}
}
Action potentials were triggered in the motor nerve by a suction electrode and calcium currents (iCa) in the nerve terminals were measured by means of a perfused macro-patch-clamp electrode on the distal portion of the end-plates. Postsynaptic currents were blocked by adding d-tubocurarine, whereas presynaptic Na+ (iNa) and K+ (iK) currents were blocked by adding tetrodotoxin (TTX), tetraethylammonium and 3,4-diaminopyridine, respectively, to the perfusate of the electrode. The current… CONTINUE READING

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