Inhibition of Ca(2+)-dependent Cl- secretion in T84 cells: membrane target(s) of inhibition is agonist specific.

@article{Barrett1998InhibitionOC,
  title={Inhibition of Ca(2+)-dependent Cl- secretion in T84 cells: membrane target(s) of inhibition is agonist specific.},
  author={Kim E Barrett and Jim Smitham and Alexis Traynor-Kaplan and Jorge M. Uribe},
  journal={The American journal of physiology},
  year={1998},
  volume={274 4},
  pages={
          C958-65
        }
}
Previous studies have indicated that Ca(2+)-dependent Cl- secretion across monolayers of T84 epithelial cells is subject to a variety of negative influences that serve to limit the overall extent of secretion. However, the downstream membrane target(s) of these inhibitory influences had not been elucidated. In this study, nuclide efflux techniques were used to determine whether inhibition of Ca(2+)-dependent Cl- secretion induced by carbachol, inositol 3,4,5,6-tetrakisphosphate, epidermal… CONTINUE READING

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