Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers

@article{Allqvist2006InhibitionOC,
  title={Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers},
  author={Annika Allqvist and Jun Miura and Leif Bertilsson and Rajaa A. Mirghani},
  journal={European Journal of Clinical Pharmacology},
  year={2006},
  volume={63},
  pages={173-179}
}
The antifungal drug ketoconazole (KTZ) is known as an inhibitor of, especially, the CYP3A subfamily, which catalyzes the metabolism of a large variety of drugs. Interactions between KTZ and CYP3A substrates have been reported both in vivo and in vitro. Most of them, however, involved the KTZ racemate. KTZ racemate and the separate enantiomers, 2R,4R; 2R,4S… CONTINUE READING