Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components.

@article{Piver2001InhibitionOC,
  title={Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components.},
  author={Bertrand Piver and François Berthou and Yvonne Dr{\'e}ano and Dani{\`e}le Lucas},
  journal={Toxicology letters},
  year={2001},
  volume={125 1-3},
  pages={83-91}
}
Resveratrol (RESV), present at concentrations of about 10 microM in red wine, has been found to inhibit events associated with tumor initiation, promotion and progression. The mechanism involved could be the inhibition of activities catalyzed by cytochromes P450 (CYPs), which activate procarcinogens. This led us to investigate the inhibitory effect of RESV on CYP1A, CYP2E1 and CYP3A enzymatic activities and to compare it to that of non volatile compounds present in red wine. Red wine solids… CONTINUE READING

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