Inhibition of CYP2D6 activity by bupropion.


The purpose of this study was to assess the effect of bupropion on cytochrome P450 2D6 (CYP2D6) activity. Twenty-one subjects completed this repeated-measures study in which dextromethorphan (30-mg oral dose) was administered to smokers at baseline and after 17 days of treatment with either bupropion sustained-release (150 mg twice daily) or matching… (More)


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@article{Kotlyar2005InhibitionOC, title={Inhibition of CYP2D6 activity by bupropion.}, author={Michael E. Kotlyar and Lisa Hartman Brauer and Timothy S. Tracy and Dorothy K. Hatsukami and Jennifer M. Harris and Carrie A. Bronars and David E. Adson}, journal={Journal of clinical psychopharmacology}, year={2005}, volume={25 3}, pages={226-9} }