Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR.

@article{Vinet2013InhibitionOC,
  title={Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR.},
  author={Jonathan Vinet and Marloes van Zwam and Ineke M. Dijkstra and Nieske Brouwer and Hilmar R J van Weering and Anne Watts and Michel M. Meijer and Michiel R. Fokkens and Vishnu Kannan and Dennis Verzijl and Henry F. Vischer and Martine J. Smit and Rob Leurs and Knut Biber and Hendrikus W. G. M. Boddeke},
  journal={British journal of pharmacology},
  year={2013},
  volume={168 6},
  pages={1375-87}
}
BACKGROUND AND PURPOSE Induction of cellular migration is the primary effect of chemokine receptor activation. However, several chemokine receptor-like proteins bind chemokines without subsequent induction of intracellular signalling and chemotaxis. It has been suggested that they act as chemokine scavengers, which may control local chemokine levels and contribute to the function of chemokines during inflammation. This has been verified for the chemokine-like receptor proteins D6 and DARC as… CONTINUE READING