Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice.

@article{Suzuki2005InhibitionOC,
  title={Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice.},
  author={Fumihito Suzuki and Toshihiro Nanki and Toshio Imai and Hirotoshi Kikuchi and Shunsei Hirohata and Hitoshi Kohsaka and Nobuyuki Miyasaka},
  journal={Journal of immunology},
  year={2005},
  volume={175 10},
  pages={6987-96}
}
Idiopathic inflammatory myopathy is a chronic inflammatory muscle disease characterized by mononuclear cell infiltration in the skeletal muscle. The infiltrated inflammatory cells express various cytokines and cytotoxic molecules. Chemokines are thought to contribute to the inflammatory cell migration into the muscle. We induced experimental autoimmune myositis (EAM) in SJL/J mice by immunization with rabbit myosin and CFA. In the affected muscles of EAM mice, CX3CL1 (fractalkine) was expressed… CONTINUE READING

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