Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A.

@article{Baroja2002InhibitionOC,
  title={Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A.},
  author={Miren L. Baroja and Lalitha Vijayakrishnan and Estelle Bettelli and Peter J. Darlington and Thu A. Chau and Vincent Ling and Mary I. Collins and Beatriz M. Carreno and Joaqu{\'i}n Madrenas and Vijay K Kuchroo},
  journal={Journal of immunology},
  year={2002},
  volume={168 10},
  pages={5070-8}
}
The catalytic subunit of the serine/threonine phosphatase 2A (PP2A) can interact with the cytoplasmic tail of CTLA-4. However, the molecular basis and the biological significance of this interaction are unknown. In this study, we report that the regulatory subunit of PP2A (PP2AA) also interacts with the cytoplasmic tail of CTLA-4. Interestingly, TCR ligation induces tyrosine phosphorylation of PP2AA and its dissociation from CTLA-4 when coligated. The association between PP2AA and CTLA-4… CONTINUE READING

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