Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages.

@article{Meijerink2015InhibitionOC,
  title={Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages.},
  author={Jocelijn Meijerink and Mieke Poland and Michiel G. J. Balvers and Pierluigi Plastina and Carolien Lute and Jvalini T. Dwarkasing and Klaske van Norren and Renger F. Witkamp},
  journal={British journal of pharmacology},
  year={2015},
  volume={172 1},
  pages={
          24-37
        }
}
BACKGROUND AND PURPOSE N-docosahexaenoylethanolamine (DHEA) is the ethanolamine conjugate of the long-chain polyunsaturated n-3 fatty acid docosahexaenoic (DHA; 22: 6n-3). Its concentration in animal tissues and human plasma increases when diets rich in fish or krill oil are consumed. DHEA displays anti-inflammatory properties in vitro and was found to be released during an inflammatory response in mice. Here, we further examine possible targets involved in the immune-modulating effects of DHEA… CONTINUE READING
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