Inhibition of COX-2 and NF-κB1 Gene Expression, NO Production, 5-LOX, and COX-1 and COX-2 Enzymes by Extracts and Constituents of Onopordum acanthium.

@article{Lajter2015InhibitionOC,
  title={Inhibition of COX-2 and NF-$\kappa$B1 Gene Expression, NO Production, 5-LOX, and COX-1 and COX-2 Enzymes by Extracts and Constituents of Onopordum acanthium.},
  author={Ildik{\'o} Lajter and San-Po Pan and Stefanie Nikles and Sabine Ortmann and Andrea Vasas and Bogl{\'a}rka Csupor-L{\"o}ffler and P{\'e}ter Forg{\'o} and Judit Hohmann and Rudolf Bauer},
  journal={Planta medica},
  year={2015},
  volume={81 14},
  pages={
          1270-6
        }
}
The present study focused on the investigation of the inhibition of cyclooxygenase-2 and nuclear factor kappa B1 gene expression, nitric oxide production, leukotriene biosynthesis (5-lipoxygenase), and cyclooxygenase-1 and cyclooxygenase-2 enzymes of Onopordum acanthium, and the isolation and identification of its active compounds. From the chloroform soluble part of the MeOH extract prepared from aerial parts, lignans [pinoresinol (1), syringaresinol (2), and medioresinol (3)] and flavonoids… 
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