Inhibition of COX-2 activity and proinflammatory cytokines (TNF-alpha and IL-1beta) production by water-soluble sub-fractionated parts from bee (Apis mellifera) venom.

@article{Nam2003InhibitionOC,
  title={Inhibition of COX-2 activity and proinflammatory cytokines (TNF-alpha and IL-1beta) production by water-soluble sub-fractionated parts from bee (Apis mellifera) venom.},
  author={Kung-woo Nam and Kang-Hoon Je and Jang Hurn Lee and Ho Je Han and Hye Jung Lee and Sung Kil Kang and Woongchon Mar},
  journal={Archives of pharmacal research},
  year={2003},
  volume={26 5},
  pages={383-8}
}
Bee venom is used as a traditional medicine for treatment of arthritis. The anti-inflammatory activity of the n-hexane, ethyl acetate, and aqueous partitions from bee venom (Apis mellifera) was studied using cyclooxygenase (COX) activity and pro-inflammatory cytokines (TNF-alpha and IL-1beta) production, in vitro. COX-2 is involved in the production of prostaglandins that mediate pain and support the inflammatory process. The aqueous partition of bee venom showed strong dose-dependent… CONTINUE READING
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